aHUS atypical Hemolytic Uremic Syndrome (aHUS) website

What is aHUS?

What are the management options and treatment for aHUS?

Although plasma exchange and plasma infusion are currently used to manage aHUS, these therapies have not been studied in
well-controlled trials.1

Plasma exchange or plasma infusion is frequently used by doctors to manage aHUS. During this process a plasma infusion is given over several hours at a specialised treatment center.2,5

However, plasma does not treat the underlying disease and no clinical studies have shown that plasma exchange therapy is safe or effective in treating aHUS.1-4 Plasma exchange/infusion is not a cure and symptoms may return over time.1,2,5,6

Dialysis or a kidney transplant may be needed for aHUS patients as a result of the damage caused by the disease. However, dialysis and kidney transplants have significant risks associated with them, and neither will actually treat or cure aHUS.7

When unregulated, the complement can lead to various severe diseases causing damages in multiple organs. Complement inhibitors are compounds which bind to enzymes in the complement system. Their role is to suppress or reduce the activity of complement.

Recent advances

As the understanding of the underlying causes of rare diseases such as aHUS has improved, researchers are finding other treatment options. Talk with your doctor about a management plan.